Activin A induction of FSHβ subunit transcription requires SMAD4 in immortalized gonadotropes
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چکیده
منابع مشابه
Constitutively Active FOXO1 Diminishes Activin Induction of Fshb Transcription in Immortalized Gonadotropes
In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene expression in immortalized LβT2 cells. We demonstrate that FOXO1 suppression of activin induction maps to the -304/-95 region of the Fshb promoter con...
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Little is known about the molecular mechanisms of androgen regulation of the FSHbeta gene; however, studies suggest that it consists of a complex feedback loop that involves multiple mechanisms acting at both the level of the hypothalamus and the pituitary. In the present study, we address androgen regulation of the FSHbeta gene in immortalized gonadotrope cells and investigate the roles of act...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2010
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme-09-0142